Search Result

Search Results for " complement c5 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T10863	Complement C5-IN-1		Complement System
	Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).		Complement System
T9915	Eculizumab		Complement System
	Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5		Complement System
T76867	Ravulizumab	ALXN1210	Complement System
	Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo...		Complement System
T77022	Gefurulimab
	Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin. It specifically binds to C5, inhibiting its activation [1].
T74431	Cemdisiran
	Cemdisiran, a conjugated siRNA with N-acetylgalactosamine (GalNAc), targets the liver to inhibit the production of complement 5 (C5) protein, serving as a potential therapeutic agent for the study of complement-mediated ...
T75106	ARC186
	ARC186 is a highly potent aptamer that serves as a complement inhibitor by blocking the convertase-catalyzed activation of C5.
T74551	Avacincaptad pegol sodium
	Avacincaptad pegol (ARC1905), an anti-C5 RNA aptamer, prevents the cleavage of complement factor 5 (C5) into fragments C5a and C5b. It is currently under investigation for the treatment of age-related macular degeneratio...
T76276	Zilucoplan
	Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide and potent complement component 5 (C5) inhibitor, is utilized in the study of immune-mediated necrotising myopathy (IMNM) [1] [2].
T77121	Pozelimab
	Pozelimab (REGN3918), a fully human IgG4 monoclonal antibody, is designed to target and bind with high affinity to both C5 and its variants, effectively inhibiting complement-mediated hemolysis. It holds potential for re...
T74552	Non-PEGylated/naked ARC1905
	ARC1905, a non-PEGylated/naked anti-C5 RNA aptamer, functions by inhibiting the cleavage of complement factor 5 (C5) into its components, C5a and C5b, without PEG conjugation. This compound is currently being researched ...
T74550	Cemdisiran, terminal sugar modification-
	Cemdisiran, an investigational N-acetylgalactosamine-conjugated RNAi (RNA interference) agent with terminal sugar modification, is a small interfering RNA (siRNA) designed to specifically target and suppress the C5 mRNA,...
T77190	Crovalimab
	Crovalimab (SKY59; RO7112689) is a novel humanized antibody designed to target C5 in a pH-dependent manner, demonstrating binding affinities (KD) of 15.2 nM and 16.8 μM at pH levels of 7.4 and 5.8, respectively. Addition...
T80083	Zilucoplan TFA	RA101495 TFA	Complement System
	Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5). It has applications in the study of immune-mediated necrotising myopathy (IMNM) [1] [2].		Complement System
T78191	NH2-C6-ARC186		Complement System
	NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules. As a potent complement inhibitor, it operates by inhibiting convertase-mediated C5 a...		Complement System
T77163	Pexelizumab
	Pexelizumab (h5G1.1-SC), a humanized scFv monoclonal antibody, targets the C5 complement component, thereby inhibiting apoptosis and leukocyte infiltration. It is utilized in researching cerebral ischemia-reperfusion (IR...
T74699	Avacincaptad pegol
	Avacincaptad pegol, a pegylated aptamer, stands out as an effective C5 complement inhibitor capable of mitigating inflammation-induced damage to the retinal pigment epithelium (RPE). This compound is under investigation ...

Compounds

Complement C5-IN-1

T10863

Synonym:

Target: Complement System

Eculizumab

T9915

Synonym:

Target: Complement System

Ravulizumab

T76867

Synonym: ALXN1210

Target: Complement System

Avacincaptad pegol sodium

Non-PEGylated/naked ARC1905

T74552

Synonym:

Target:

Cemdisiran, terminal sugar modification-

Synonym: RA101495 TFA

Target: Complement System

NH2-C6-ARC186

T78191

Synonym:

Target: Complement System

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00653	Complement C5 Protein, Human, Recombinant (Complement C5a)	Human	E. coli
	Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is P01031.
TMPY-05057	Complement C5 Protein, Human, Recombinant (His & FLAG)	Human	HEK293 Cells
	Complement C5 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 188.8 kDa and the accession number is P01031.
TMPH-03270	Complement C5 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.0 kDa and the accession number is P08650.
TMPY-06814	Complement C5 Protein, Human, Recombinant (Flag)	Human	HEK293 Cells
	Complement C5 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with Flag tag. The predicted molecular weight is 187.36 kDa and the accession number is NP_001726.2.
TMPY-06538	Complement C5 Protein, Cynomolgus, Recombinant	Cynomolgus	HEK293 Cells
	Complement C5 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 8.41 kDa and the accession number is XP_005580972.1.
TMPH-03107	Complement C5a Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	P. pastoris (Yeast)
	Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, ...
TMPY-06137	Complement C5 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Complement C5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 188.1 kDa and the accession number is XP_005580972.1.
TMPK-01268	Complement C2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to health...
TMPH-02607	Complement factor B Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convert...
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to fo...
TMPH-02845	Properdin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Comple...
TMPH-02844	Properdin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Comple...
TMPJ-00149	Complement Factor D/CFD Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement a...
TMPH-02605	Complement C4-B Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of imm...
TMPH-01134	Complement C8g Protein, Human, Recombinant (His)	Human	E. coli
	C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind ...
TMPJ-00585	Complement C8 gamma Protein, Human, Recombinant (His)	Human	E. coli
	Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 ...